不同途径感染猪血球凝集性脑脊髓炎病毒的比较病理学

用传代鼠血球凝集性脑脊髓炎病毒接种液，经不同途径感染12头5日龄仔猪作比较病理学研究。结果表明，经脑内注射、前后肢肌肉注射、口服、口服兼滴鼻等途径接种的仔猪全部感染发病，并在接种后36～98h死亡。发病猪出现脑、脊髓的小静脉和毛细管充血、出血、水肿，神经原水肿、急性肿胀、急性液化及中央染色质溶解，胶质细胞轻微增生等非化脓性脑脊髓炎特征。口服兼滴鼻接种猪脑脊髓出血、脑水肿最明显，神经原变质也最重。脑内接种猪脑膜的血管周围出现明显的免疫细胞反应。

Comparative Pathology of Piglets Infected with Hemagglutinating Encephalomyelitis Virus in Different Inoculation

Five day old piglets were infected in different inoculation with the hemagglutinating encephalomyelitis virus(HEV) prepared from brain of passage mice.The results showed that all experimental piglets,which were inoculated in intrabrain injection,intramuscular injection of forward and latter legs,and by mouth and nose,died after the inoculation of 36 to 98 hours.All experimental piglets revealed the characteristic nonpurulent encephalomyelitis,such as hyperemia,hemorrhage,edema in little vein and capillary vessel of brain and spinal cord.There were also edema,swollen,liquefication in nerve cells,and solution in central chromatin as well as slight proliferation in glia cells.In addition,the most obvious pathological inspections were cerebrospinal hemorrhage,cerebral edema,and severe denaturation in nerve cells for sick piglets inoculated by mouth and nose.There was quite obvious immune cell reaction around blood vessel of meninx for sick piglets by intra brain inoculation.