Effects of chloramphenicol on the development of immune responses to canine distemper virus in Beagle pups |
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| Authors: | P L NARA L E DAVIS L H LAUERMAN† JANICE E COYLE-DENNIS‡ J PAUL§ |
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| Institution: | †Veterinary Diagnostic Laboratory, P.O. Box 2209, Auburn, Alabama 36830;‡Department of Microbiology, College of Veterinary Medicine, Colorado State University, Ft Collins, Colorado 80523;§American Hoechst Corp., Route 202–206 N., Somerville, New Jersey, U.S.A.;Department of Veterinary Pathobiology, The Ohio State University, Columbus, Ohio 43210, U.S.A. |
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| Abstract: | The effect of oral chloramphenicol (CHPC) on the development of immune responses to canine distemper virus (CDV) in Beagle pups was studied. Dogs were treated with CHPC for 14 days at a dose of 50 mg/kg, three times a day. Hematologic changes in CHPC-treated dogs included: polychromasia, anisocytosis, and target cell formation of red blood cells concurrent with vacuolation of lymphocytes and basophilic granule formation in neutrophils. Dogs given this therapy showed normal in vivo and in vitro immune responses after CDV vaccination and survived a virulent CDV challenge, whereas untreated, unvaccinated dogs became ill or died after challenge exposure. The results of this study indicate that CHPC therapy does not interfere with either the prechallenge immune response to attenuated viral antigen or the efficient immune mechanisms invoked during virulent virus challenge. |
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