Immunoadjuvant activity of crude lectin extracted from Momordica charantia seed |
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Authors: | Huang Li Ikejiri Ai Shimizu Yuya Adachi Takumi Goto Yoshitaka Toyama Jun Tanaka Hidenori Akashi Ryo Uchida Kazuyuki Miyata Hironori Haga Takeshi |
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Institution: | Department of Veterinary Microbiology, University of Miyazaki, Miyazaki, Japan. |
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Abstract: | The aim of this study is to investigate the immunoadjuvant activity of the crude Momordica charantia lectin (crMCL) extracted from seed using beta-galactosidase (beta-gal) as the model antigen. BALB/c mice were injected intramuscularly with beta-gal alone or beta-gal + crMCL for up to four immunizations at two-week intervals. After administration of 2 doses, the IgG-specific titer to beta-gal was significantly higher in mice in the beta-gal + crMCL group than in that from the animals from the beta-gal alone group, while it was about the same in both groups after 1 dose. Our data suggest that crMCL may help raise antibodies under the prime and boost administration regimen and could be a potent vaccine adjuvant. |
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