Effects of Pithecellobium clypearia Benth extract and its main components on inflammation and allergy |
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| Authors: | Li Bao Xinsheng Yao Jiekun Xu Xiaoyu Guo Hongwei Liu Hiroshi Kurihara |
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| Institution: | 1. Key Lab of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China;2. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China;3. Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, PR China;4. School of Pre-clinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, PR China;5. School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China |
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| Abstract: | The ethanol extract of Pithecellobium clypearia Benth (PCE) was characterized to be rich in polyphenols by HPLC analysis, and investigated for its anti-inflammatory and anti-allergic activities. In our assay, PCE showed anti-inflammatory activity in both acute and auto-immune inflammation animal models. Administration of PCE can effectively inhibit the croton oil-induced ear edema and capillary permeability, the carrageenin-induced paw edema, and the liver injury caused by propionibacterium acnes plus lipopolysaccharide. PCE was also found to possess anti-allergic activity in inhibiting the DNFB-induced delayed hypersensitivity reaction. Meanwhile, seven main components (1–7) from PCE were studied for their effect on histamine release stimulated by compound 48/80 from rat peritoneal mast cells in vitro. Compound 2 ((−)-epigallocatechin-7-gallate), 3 ((−)-5, 7, 3′, 4′, 5′-pentahydroxyflavan), and 5 ((−)-tetra hydroxyflavan-7-gallate) showed significant inhibition effect on histamine release. |
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| Keywords: | Pithecellobium clypearia Benth Anti-inflammatory Anti-allergy Histamine release |
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