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Pharmacokinetics of carprofen and firocoxib for medication control in racing greyhounds |
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| Authors: | TH Morris SW Paine PW Zahra EC Li SA Colgan SL Karamatic |
| Institution: | 1. School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK;2. Racing Analytical Services Limited, Flemington, Victoria, Australia;3. Racing Analytical Services Limited, Flemington, Victoria, Australia
Agilent Technologies Australia, Mulgrave, Victoria, Australia;4. SCEC Eurofins, Northbridge, New South Wales, Australia;5. Greyhound Racing Victoria, West Melbourne, Victoria, Australia |
| Abstract: | Animals used in sport should be treated as required to ensure animal welfare but any such use of medication should also be controlled to ensure integrity. Pharmacokinetic studies on groups of six greyhounds were performed to measure plasma and urine levels of carprofen and firocoxib to inform medication control advice. Using the standard methodology for medication control the Irrelevant Plasma Concentration was determined as 20 and 2 ng/mL for carprofen and firocoxib, respectively. The Irrelevant Urine Concentration was also determined as 0.3 and 2 ng/mL for carprofen and firocoxib, respectively. These Irrelevant Plasma and Urine Concentrations will allow laboratory Screening Limits, Detection Times and Withdrawal Time advice to be determined and publicised by regulators of greyhound racing. The Screening Limits will also inform Recommended Limits of Detection if meat-containing residues of these medications are fed to greyhounds. |
| Keywords: | carprofen firocoxib greyhound pharmacokinetics racing |