Characterization of canine platelet activation induced by platelet activating factor (PAF) |
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| Authors: | Tsuchiya Ryo Tatsuki Yumiko Kitao Satoshi Furuichi Mitsuru Neo Sakurako Hisasue Masaharu Yamada Takatsugu Kobayashi Kosaku |
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| Institution: | School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan. tsutiyar@azabu-u.ac.jp |
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| Abstract: | Characteristics of the signal transduction in Platelet activating factor (PAF)-activated platelets and effects of anti-platelet agents on this response were investigated in vitro for potential therapeutic applications in canine endotoxemia. Blockade of the PAF receptor by a specific blocker has the strongest inhibitive effect on the PAF-induced platelet reactions. The response was also inhibited by either Ca(2+) channel blockers or prostaglandin E(1). |
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