nardosinane-type sesquiterpenoids from the formosan soft coral Paralemnalia thyrsoides |
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| Authors: | Huang Chiung-Yao Su Jui-Hsin Chen Bo-Wei Wen Zhi-Hong Hsu Chi-Hsin Dai Chang-Feng Sheu Jyh-Horng Sung Ping-Jyun |
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| Affiliation: | Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan. betty8575@yahoo.com.tw |
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| Abstract: | Five new nardosinane-type sesquiterpenoids, paralemnolins Q-U (1-5), along with three known compounds (6-8), were isolated from the Formosan soft coral Paralemnalia thyrsoides. The structures of new metabolites were elucidated on the basis of extensive spectroscopic methods, and the absolute configuration of 1 was determined by the application of Mosher's method on 1. Among these metabolites, 1 and 3 are rarely found nardosinane-type sesquiterpenoids, possessing novel polycyclic structures. Compounds 1, 3, 6 and 7 were found to possess neuroprotective activity. |
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| Keywords: | soft coral Paralemnalia thyrsoides nardosinane neuroprotective activity |
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