Clinical, histopathological and immunohistochemical findings in a case of megakaryoblastic leukemia in a dog. |
| |
| Authors: | Hee-Myung Park Alan R Doster Roksana E Tashbaeva Young-Mee Lee Young S Lyoo Sang-Jin Lee Hee-Jung Kim Jung-Hyang Sur |
| |
| Affiliation: | Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul, KwangJin-Ku 143-701, Korea. |
| |
| Abstract: | The clinical, hematological, and histopathologic features of megakaryoblastic leukemia (M7) were investigated in a 10-year-old female Shih-Tzu dog. Megakaryoblastic leukemia was diagnosed using anti-human platelet glycoprotein (GP IIIa) and anti-human von Willebrand factor (vWF) antibodies. The expression of CD antigen on megakaryoblasts was also assessed using a CD79a monoclonal antibody. Immunological markers allowed visualization of neoplastic megakaryocytes. Antibodies against platelet GP IIIa were demonstrated to be the most useful for the diagnosis of megakaryoblastic leukemia of paraffin-embedded canine tissues. Hematological and histological data coupled with immunohistochemical reactivity for platelet GP IIIa, vWF, and CD79a antigen in blast cells confirmed a diagnosis of M7 megakaryoblastic leukemia. |
| |
| Keywords: | |
|
|
