Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy |
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| Authors: | Germán J Cantón Frank Katzer Stephen W Maley Paul M Bartley Julio Benavides-Silván Javier Palarea-Albaladejo Yvonne Pang Sionagh H Smith Mara S Rocchi David Buxton Elisabeth A Innes Francesca Chianini |
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| Institution: | 1.Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, UK;2.Instituto Nacional de Tecnología Agropecuaria (INTA), EEA Balcarce, Balcarce 7620, Argentina;3.Instituto de Ganadería de Montaña (CSIC-ULE), León 24346, Spain;4.Biomathematics and Statistics Scotland, Edinburgh EH9 3JZ, UK;5.Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK |
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| Abstract: | Infection with Neospora caninum stimulates host cell-mediated immune responses, which may be responsible for placental damage leading to bovine abortion. The aim of this study was to compare immune responses in the bovine placenta, following experimental infection in different stages of pregnancy. Placentomes were examined by immunohistochemistry and inflammation in early gestation was generally moderate to severe, particularly in the placentas carrying non-viable foetuses, whereas it was milder in later stages, mainly characterised by the presence of CD3+, CD4+ and γδ T-cells. This distinctive cellular immune response may explain the milder clinical outcome observed when animals are infected in later gestation. |
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