| 顶复门原虫3-磷酸甘油醛脱氢酶功能及其应用研究进展 |
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| 引用本文： | 廖申权,戚南山,吴彩艳,吕敏娜,袁建丰,余劲术,孙铭飞.顶复门原虫3-磷酸甘油醛脱氢酶功能及其应用研究进展[J].中国畜牧兽医,2012,39(1):71-74. |
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| 作者姓名： | 廖申权 戚南山 吴彩艳 吕敏娜 袁建丰 余劲术 孙铭飞 |
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| 作者单位： | 广东省农业科学院兽医研究所 广东省兽医公共卫生公共实验室,广东广州 510640 |
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| 基金项目： | 广东省国际科技合作专项(2008A050200015);广东省自然科学基金项目(1045106001006126);广东省农业科学院院长基金项目(201014,201115);广东省农业科学院兽医研究所所长基金项目 |
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| 摘 要： | 糖酵解途径广泛存在于各类生物中,是顶复门原虫的主要供能方式。3-磷酸甘油醛脱氢酶是糖酵解途径的重要酶,与顶复门原虫的生存密切相关,可以作为抗寄生虫药物研发的重要靶标。文章主要从顶复门原虫糖酵解途径、3-磷酸甘油醛脱氢酶的基因分析、作用机理及应用等方面进行综述。
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| 关 键 词： | 顶复门原虫 3-磷酸甘油醛脱氢酶 药物靶标 |
| 收稿时间： | 2011-05-31 |
Research Advances on the Function and Application of Glyceraldehydes-3-phosphate Dehydrogenase in Apicomplexa |
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| LIAO Shen-quan
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QI Nan-shan
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WU Cai-yan
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LV Min-na
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YUAN Jian-feng
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YU Jin-shu
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SUN Ming-fei.Research Advances on the Function and Application of Glyceraldehydes-3-phosphate Dehydrogenase in Apicomplexa[J].China Animal Husbandry & Veterinary Medicine,2012,39(1):71-74. |
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| Authors: | LIAO Shen-quan QI Nan-shan WU Cai-yan LV Min-na YUAN Jian-feng YU Jin-shu SUN Ming-fei |
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| Institution: | Guangdong Common Lab of Veterinary Public Health,Institute of Veterinary Medicine, Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China |
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| Abstract: | Glycolysis exists in various organisms.It is the major energetic process in apicomplexan parasites.Glyceraldehyde-3-phosphate dehydrogenase(GAPDH) plays an important role in glycolysis,which closely related to the survival of parasites.GAPDH is proposed to be a potential target for antiparasitic drugs.This review will focus on glycolysis and the genetic analysis,mechanism and application of glyceraldehydes-3-phosphate dehydrogenase in Apicomplexa. |
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| Keywords: | Apicomplexa glyceraldehyde-3-phosphate dehydrogenase(GAPDH) drug target |
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