犊牛遗传性小脑萎缩共济失调研究

本文首次报导了犊牛遗传性运动失调症的综合研究情况。指出渐进性共济失调(摇头、叉开站立、行走不稳)为示病症状,小滴萎缩及蒲氏细胞层的变性为示病病变。诊断时尚须与脑包虫、小脑肿瘤、前庭神经麻痹等相鉴别、根据病理组织学和临床症状特点,作者建议将本病按小脑型、脊髓型、小脑脊髓型分类、本病发生于父母繁殖的二、三代,属于隐性遗传。本病发病率分别占该父女近亲繁殖二、三代总后裔的6.1％、11％,即级进二代健康后裔与患者的比数接近15∶1,9∶1。作者用孟德尔自由组合规律的重叠作用理解释了这一遗传现象,本报告真实地报导了作者拟定的防制措施及其在实践中取得的效益,证明淘汰有害基因携带者及可疑者禁止近亲繁殖是杜绝本病发生的有效措施。本文为临床遗传学的研究提供了罕见的素材。

THE STUDY ON HEREDO-CEREBELLAR-ATROPHY-ATAXIA ILFN CALF

This paper reports the condition of the sythetic study on calf heredoataxia cerebellaris and points out that the gradual ataxia such as shaking one's head, standing by pushing aside with both feet, walking shakily ect is pathognomonic symptom, that the cerebellar atrophy and purkinje-cell-storey degeneration, are pathognomonic changes in pathology. We should differ this disease from coenurosis, cerebellar neoplasma and paralysis nervi vestibularis ect. According to their pathological and clinical characteristic, the author suggests that these diseases should be class into three types: cerebellar.spinoneural, cerebellar-spinoneural. These recessive genetic diseases occured in secondary and third filial of nearsighted generation. The attack rate of secondary filial was 6.29％. The score of healths and patients in F2 neared 15 to 1. The author explians this genetic phenomenon with freedom combination rule and multiple action principle of mendel. The report deuls really with the control mensurement established by author and it's subtantial effect. Eliminating carrier of harmful gene—the ox and prohibiting nearsighed generation bave been proved to be an effective measurement for eliminating this disease.