The metabolic response to norepinephrine in carbon tetrachloride poisoned sheep

The intraruminal administration of carbon tetrachloride to healthy sheep caused a sharp rise in the serum OCT levels. The plasma concentration of non-esterified fatty acids (NEFA) increased, while blood glucose remained unaffected. The glucose response to the intravenous injection of norepinephrine was greatly reduced after carbon tetrachloride administration, indicating a depletion of the liver glycogen. The NEFA response was not altered. As the increase in NEFA caused by carbon tetrachloride was only moderate, a block in lipoproteinsynthesis is discussed as the main factor in the development of the fatty liver.