Antidiabetic Activity of Differently Regioselective Chitosan Sulfates in Alloxan-Induced Diabetic Rats |
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| Authors: | Ronge Xing Xiaofei He Song Liu Huahua Yu Yukun Qin Xiaolin Chen Kecheng Li Rongfeng Li Pengcheng Li |
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| Institution: | 1.Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; E-Mails: (X.H.); (S.L.); (H.Y.); (Y.Q.); (X.C.); (K.L.); (R.L.);2.College of Earth Science, University of the Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | The present study investigated and compared the hypoglycemic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats. Compared with the normal control rats, significantly higher blood glucose levels were observed in the alloxan-induced diabetic rats. The differently regioselective chitosan sulfates exhibited hypoglycemic activities at different doses and intervals, especially 3-O-sulfochitosan (3-S). The major results are as follows. First, 3,6-di-O-sulfochitosan and 3-O-sulfochitosan exhibited more significant hypoglycemic activities than 2-N-3, 6-di-O-sulfochitosan and 6-O-sulfochitosan. Moreover, 3-S-treated rats showed a more significant reduction of blood glucose levels than those treated by 3,6-di-O-sulfochitosan. These results indicated that –OSO3− at the C3-position of chitosan is a key active site. Second, 3-S significantly reduced the blood glucose levels and regulated the glucose tolerance effect in the experimental rats. Third, treatment with 3-S significantly increased the plasma insulin levels in the experimental diabetic rats. A noticeable hypoglycemic activity of 3-S in the alloxan-induced diabetic rats was shown. Clinical trials are required in the future to confirm the utility of 3-S. |
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| Keywords: | differently regioselective chitosan sulfates hypoglycemic activity glucose tolerance plasma insulin alloxan-induced diabetic rats |
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