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Molecular Architecture and Biomedical Leads of Terpenes from Red Sea Marine Invertebrates
Authors:Mohamed Elamir F. Hegazy  Tarik A. Mohamed  Montaser A. Alhammady  Alaa M. Shaheen  Eman H. Reda  Abdelsamed I. Elshamy  Mina Aziz  Paul W. Paré
Abstract:Marine invertebrates including sponges, soft coral, tunicates, mollusks and bryozoan have proved to be a prolific source of bioactive natural products. Among marine-derived metabolites, terpenoids have provided a vast array of molecular architectures. These isoprenoid-derived metabolites also exhibit highly specialized biological activities ranging from nerve regeneration to blood-sugar regulation. As a result, intense research activity has been devoted to characterizing invertebrate terpenes from both a chemical and biological standpoint. This review focuses on the chemistry and biology of terpene metabolites isolated from the Red Sea ecosystem, a unique marine biome with one of the highest levels of biodiversity and specifically rich in invertebrate species.
Keywords:terpenes   Red Sea   marine ecosystem   marine invertebrates   biomedical leads
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