Obstructive nephropathy induced with DL-potassium hydrogen tartrate in F344
rats |
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Authors: | Kaoru Inoue Tomomi Morikawa Miwa Takahashi Midori Yoshida Kumiko Ogawa |
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Institution: | 1.Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya, Tokyo 158-8501, Japan |
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Abstract: | We experienced obstructive nephropathy in F344 rats treated with DL-potassium hydrogen
tartrate (PHT) in a 13-week oral repeated dose toxicity study. Six-week-old male and
female F344/DuCrj rats were fed a diet containing up to 2.0% PHT for 13 weeks.
Microscopical findings including irregular dilation of the distal tubule lumen, foreign
body giant cells, inflammatory cell infiltration, and regeneration of renal tubules were
observed focally or multifocally in the renal cortex and/or medulla in the 0.5% and higher
dosage groups of both sexes. The severity of these lesions increased in a dose-dependent
manner. In the urinalysis, an increase in protein and white blood cells or the
concentration of tartaric acid was detected in the 0.5% PHT and higher dosage groups of
both sexes or males, respectively, though conventional blood biochemical analysis did not
indicate failure of renal function. These results indicate that the PHT induces
obstructive nephropathy in rats. There were no other treatment-related changes in other
organs. |
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Keywords: | obstructive nephropathy rat kidney DL-potassium hydrogen tartrate |
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