Capgermacrenes A and B,Bioactive Secondary Metabolites from a Bornean Soft Coral,Capnella sp. |
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| Authors: | Chin-Soon Phan Shean-Yeaw Ng Eun-A Kim You-Jin Jeon Kishneth Palaniveloo Charles Santhanaraju Vairappan |
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| Institution: | 1.Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia; E-Mails: (C.-S.P.); (S.-Y.N.); (K.P.);2.Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea; E-Mail: |
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| Abstract: | Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulation of the LPS-induced pro-inflammatory IL-1β and NO production by down-regulating the expression of iNOS protein in RAW 264.7 macrophages. |
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| Keywords: | soft coral Capnella sp Nephtheidae sesquiterpenoids bicyclogermacrene |
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