Mechanisms of Mycotoxin-induced Dermal Toxicity and Tumorigenesis Through Oxidative Stress-related Pathways |
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| Authors: | Kunio Doi Koji Uetsuka |
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| Affiliation: | 1. Bozo Research Center Inc., 8 Ohkubo, Tsukuba, Ibaraki 300-2611, Japan;2. Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan;3. Animal Health Laboratory, College of Agriculture, Ibaraki University, 3-21-1, Ami-machi, Inashiki-gun, Ibaraki 300-0393, Japan |
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| Abstract: | Among the many mycotoxins, T-2 toxin, citrinin (CTN), patulin (PAT), aflatoxin B1 (AFB1) and ochratoxin A (OTA) are known to have the potential to induce dermal toxicity and/or tumorigenesis in rodent models. T-2 toxin, CTN, PAT and OTA induce apoptosis in mouse or rat skin. PAT, AFB1 and OTA have tumor initiating properties, and OTA is also a tumor promoter in mouse skin. This paper reviews the molecular mechanisms of dermal toxicity and tumorigenesis induced in rodent models by these mycotoxins especially from the viewpoint of oxidative stress-mediated pathways. |
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| Keywords: | dermal toxicity dermal tumorigenesis T-2 toxin citrinin patulin aflatoxin B1 ochratoxin A |
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