Increased calcium deposits and decreased Ca-ATPase in erythrocytes of ascitic broiler chickens |
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| Authors: | Kai Li Lihong Zhao Guangrui Geng Liqin Ma Shishan Dong Tong Xu Jianlin Wang Huiyu Wang Yong Tian Jian Qiao |
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| Affiliation: | a Department of Animal Physiopathology, College of Veterinary Medicine, China Agricultural University, Beijing 100193, PR China;b Department of Veterinary Medicine, College of Animal Science, Hebei North University, Hebei Province 075000, PR China |
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| Abstract: | The decrease of erythrocyte deformability may be one of the predisposing factors for pulmonary hypertension and ascites in broiler chickens. In mammals, the cytoplasmic calcium is a major regulator of erythrocyte deformability. In this study, the erythrocyte deformability was measured, and the precise locations of Ca2+ and Ca2+-ATPase in the erythrocytes were investigated in chickens with ascites syndrome induced by low ambient temperature. The results showed that ascitic broilers had higher filtration index of erythrocyte compared with control groups, indicating a decrease in erythrocyte deformability in ascitic broilers. The more calcium deposits were observed in the erythrocytes of ascitic broilers compared with those of the age-matched control birds. The Ca2+-ATPase reactive grains were significantly decreased on the erythrocyte membranes of ascitic broilers. Our data suggest that accumulation of intracellular calcium and inhibition of Ca2+-ATPase might be important factors for the reduced deformability of the erythrocytes of ascitic broilers. |
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| Keywords: | Broiler Ascites syndrome Erythrocytes Calcium deposits Ca2+-ATPase |
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