| 新化合物1，4-二氧喹喔啉-3-甲醛缩氨基硫脲-2-甲酸乙酯的合成及抑菌活性 |
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| 引用本文： | 孔新刚,郭明,毛胜凤,李华,俞飞.新化合物1，4-二氧喹喔啉-3-甲醛缩氨基硫脲-2-甲酸乙酯的合成及抑菌活性[J].浙江林学院学报,2008,25(6):685-688. |
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| 作者姓名： | 孔新刚 郭明 毛胜凤 李华 俞飞 |
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| 作者单位： | 1. 新疆农业大学,动物科学学院,新疆,乌鲁木齐,830052
2. 浙江林学院,理学院,浙江,临安,311300 |
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| 基金项目： | 浙江省科学技术重点计划
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浙江省林业厅资助项目
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| 摘 要： | 以1，4-二氧喹喔啉-3-甲基-2-甲酸乙酯和氨基硫脲为原料，经氧化缩合反应，合成了化合物1，4-二氧喹喔啉-3-甲醛缩氨基硫脲-2-甲酸乙酯。通过元素分析、质谱分析、红外光谱、1H NMR对其结构进行了表征，并采用滤纸片法研究化合物对9种指示菌的抑菌效果。结果表明，该化合物对细菌具有较强抑菌活性，对真菌无抑菌活性。图4参11
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| 关 键 词： | 1 4-二氧喹喔啉 有机合成 结构表征 抑菌活性 |
Study on the bacteriostasis of 2-ethylformate-3-formaldehyde thiosemiearbazone-quinoxaline- 1, 4-dioxide |
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| KONG Xin-gang,GUO Ming,MAO Sheng-feng,LI Hua,YU Fei.Study on the bacteriostasis of 2-ethylformate-3-formaldehyde thiosemiearbazone-quinoxaline- 1, 4-dioxide[J].Journal of Zhejiang Forestry College,2008,25(6):685-688. |
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| Authors: | KONG Xin-gang GUO Ming MAO Sheng-feng LI Hua YU Fei |
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| Abstract: | A new 2-ethylformate-3-formaldehyde thiosemicarbazone-quinoxaline-1,4-dioxide was synthesized by oxidizing and condensation reaction.The structure of product was characterized by elemental analyses,MS,IR and 1H NMR.And the antibacterial activity of the product against 9 indicative microorganisms was studied by disk diffusion method.The result showed that the compound had strong inhibitory activity against bacteria,but no inhibitory activity against fungi was observed.Ch,4 fig.11 ref.] |
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| Keywords: | quinoxaline-1 4-dioxide organic synthesis characterization antibacterial activity |
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