Toxicity of halogenated oxyquinolines in dogs. A clinical study. IV. Tissue distribution and elimination in urine

LANNEK, BIRGITTA and PAUL LINDBERG: Toxicity of halogenated oxyquinolines in dogs. A clinical study. IV. Tissue distribution and elimination in urine. Acta vet. scand. 1974, 15, 419–435. — Distribution studies using ¹²⁵I-labelled vioform given orally showed higher blood activity when fat was ingested. It is assumed that this is due to increased absorption from the gastrointestinal tract. Total activity eliminated in urine during 12 hrs. was well correlated with blood activity.Distribution of activity in blood and tissues in dogs which were intoxicated and died did not show any significant traits as compared to dogs which remained healthy. The mortality was highest in dogs which were fed with fouled herring before the administration of fat and vioform.vioform toxicity; halogenated oxyquinolines.