复合锌硒片对尘肺患者血清脂质过氧化水平和微量元素的影响

目的探讨复合锌硒片对尘肺患者血清脂质过氧化水平及微量元素含量的影响.方法将80例单纯Ⅰ期尘肺患者分成治疗组和对照组,治疗组在内科常规治疗基础上加用复合锌硒片治疗3个月.测定服药前、服药1个月后血清SOD,MDA的含量及微量元素锌、硒及铜的含量.结果对照组患者治疗前后血清SOD活力、MDA及硒、锌、铜含量差异无显著性（P〉0.05）,而治疗组患者治疗后血浆SOD活力显著升高,MDA含量降低,微量元素锌、硒含量增高,与治疗前差异有显著性（P〈0.01）,与对照组治疗后相比也有显著性差异（P〈0.01）.结论复合锌硒片能调整体内微量元素比例,提高尘肺患者抗氧化作用,可用于尘肺病的辅助治疗.

Effect of Combination of Zinc and Selenium on Antioxidant Level and Trace Elements of Pneumoconiosis Patients

Objective To investigate the effect of combination of zinc and selenium on antioxidant level and trace elements of pneumoconiosis patients.Method 80 patients with pneumoconiosis of stage Ⅰwere randomly assigned to the treatment group（40 cases）and the control group（40 cases）.Those patients in treatment group were treated with combination of zinc and selenium for 3 months added to routine medical treatment.SOD activity and MDA,Se,Zn Cu content of serum were determined in two groups pre and post treatment.Results In the control group,there was no significant difference on the activities of SOD and the content of MDA and trace elements between pre and post treatment（P0.05）.While in the treatment group,the activities of SOD and the content of Se,Zn increased significantly and the content of MDA decreased obviously after treatment（P0.01）.Conclusion The results show that combination of zinc and selenium can adjust the ratio of trace elements and increase antioxidant level for patients with pneumoconiosis,it can be used for the adjuvant treatment of pneumoconiosis.