山羊痘病变的超微病理学研究

对发生在贵州省的山羊痘病变进行了透射电镜观察。在感染的皮肤和肺上皮细胞的胞浆内发现有大量不同成熟阶段的典型的山羊痘病毒颗粒。病毒颗粒也可见于巨噬细胞、成纤维细胞、血管内皮细胞的胞浆内，甚至少量在血管腔内。受感染的细胞除可见胞浆内散在的病毒颗粒或形成病毒包涵体外，通常可见细胞水肿，线粒体肿胀，内质网和高尔基复合体扩张。一个有趣但十分重要的发现是，有髓神经纤维也被病毒和被感染的巨噬细胞所波及，并可见节段性脱髓鞘以及轴索和雪旺氏细胞的变性。在山羊痘痘疹材料感染鸡胚绒毛尿囊膜痘斑的上皮细胞和成纤维细胞中也可见成熟和不成熟的病毒颗粒。

Ultra-structural Pathological Observation on the Lesions of Goat Pox

The lesions of goat pox in Guizhou Province were observed using transmission electronic microscopy. Numerous typical goat poxvirus in different mature stages were found in the cytoplasma of the affected epithelial cells in skin and lung, and some also could be found in the cytoplasma of macrophages, fibroblastic cells and vascular endothelial cells with a few within the blood vessels. Besides the virus diffused or restricted as a virus inclusion body in the cytoplasm, the affected cells are usually swelling with enlarged cell organs such as mitochondrion, endoplasmic reticulum and Golgi complex. An interesting and important finding is that myelinated nerve fibers were also involved by the virus and affected macrophages and segmental demyelination with degeneration of axon and Schwann cells were noted. The typical matured or maturing virus particles were also found in the epithelial cells and the fibroblastic cells in the affected chorioallantoic membrane of chick embryo.