| 加替沙星的电化学特性及其应用 |
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| 引用本文： | 赵云芳,张晓丽.加替沙星的电化学特性及其应用[J].山西农业大学学报(自然科学版),2009,29(4):370-373. |
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| 作者姓名： | 赵云芳 张晓丽 |
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| 作者单位： | 1. 山西农业大学,文理学院,山西,太谷,030801
2. 山东大学,化学与化工学院,山东,济南,250100 |
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| 基金项目： | 山西农业大学科技创新基金项目 |
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| 摘 要： | 用电化学预处理法制备了新型的玻碳电极(PGCE),并在此电极上用循环伏安法和线性扫描伏安法研究了加替沙星(GFLX)的电化学特性。结果表明,在浓度为0.03 mol.L-1,pH为5.0的NaAc-HAc缓冲溶液中,电压为+0.20V条件下富集120 s后,GFLX在+1.05V(vs.SCE)处产生一个灵敏的不可逆氧化吸附峰。氧化峰电流ip与GFLX浓度在6.0×10-8~1.0×10-5mol.L-1范围内呈良好的线性关系,检测下限可达1.0×10-8mol.L-1。该电极可用于直接测定尿样中加替沙星的含量,与其他分析方法相比,结果比较理想。
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| 关 键 词： | 加替沙星 玻碳电极 吸附伏安法 |
The electrochemical characters of Gatifloxacin and Its Analytical Application |
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| ZHAO Yun-fang,ZHANG Xiao-li.The electrochemical characters of Gatifloxacin and Its Analytical Application[J].Journal of Shanxi Agricultural University,2009,29(4):370-373. |
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| Authors: | ZHAO Yun-fang ZHANG Xiao-li |
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| Abstract: | A new electrochemically pretreated glassy carbon electrode(PGCE) was fabricated and used for the determination of gatifloxacin by cyclic and linear sweep voltammetry.Cyclic voltammetric studies indicated that the process was irreversible and fundamentally controlled by adsorption.With 120 s accumulation at +0.20V(vs.SCE),a sensitive oxidation peak was observed at +1.05V(vs.SCE) in 0.03 mol·L-1 pH 5.0 acetate buffer.The linear range was 6.0×10-8 ~ 1.0×10-5 mol·L-1.The detection limit was 1.0×10-8 mol·L-1.The PGCE was applied for the direct determination of gatifloxacin in human urine samples without any pre-treatment. |
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| Keywords: | Gatifloxacin Glassy carbon electrode Adsorptive voltammetry |
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