2型糖尿病中医六经辨证与临床生化指标的关系

目的 探讨2型糖尿病六经辨证分型与临床相关生化指标之间的关系。方法 收集2型糖尿病患者184例，非糖尿病住院患者30例作为对照组。记录患者六经辨证分型、年龄、病程、体质量指数（BMI）、空腹血糖（FPG）、糖化血红蛋白（HbA1c）、甘油三酯（TG）、胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、空腹胰岛素（FINS）、空腹C肽（C-P），并分析不同证型之间指标的关系。结果 2型糖尿病分型以少阴证最多见（52.17%），且年龄最大，与其他证型比较差异具有统计学意义（P<0.05）；少阴证病程较长，与阳明证相比差异具有统计学意义（P<0.05）；少阴证、少阳证、阳明证HDL-C均低于对照组，LDL-C均高于对照组，所有证型组TG均高于对照组，其中少阴证、少阳证HDL-C高于阳明证，少阴证TG高于少阳证，差异均具有统计学意义（P<0.05）。结论 2型糖尿病患者尤其是年长及病程较久患者，治疗上应注重温阳散寒；不同证型的HDL-C、TG水平不同，对糖尿病六经辨证治疗具有一定参考价值；少阴证、少阳证、阳明证型患者在治疗上应注重调脂治疗。

Relationship Between TCM Six-Meridian Syndrome Differentiation Types and Biochemical Parameters in Patients with Type 2 Diabetes

Objective To investigate the relationship between traditional Chinese medicine six-meridian syndrome differentiation types and biochemical parameters in patients with type 2 diabetes. Methods A total of 184 patients with type 2 diabetes were collected and 30 non-diabetic inpatients were chosen as control group. The relationship of age, duration of disease, body mass index, fasting blood glucose, and levels of glycosylated hemoglobin, triglyceride (TG), cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting insulin, and fasting C-peptide with six-meridian syndrome differentiation types was analyzed, and these parameters were compared between the different syndrome types. Results Shaoyin syndrome was the most common type of type 2 diabetes (52.17%). The Shaoyin syndrome group had significantly older age than the other syndrome groups (P<0.05). The Shaoyin syndrome group had a significantly longer duration of disease than the Yangming syndrome group (P<0.05). Compared with the control group, the Shaoyin syndrome group, Shaoyang syndrome group, and Yangming syndrome group had a significantly lower HDL-C level (P<0.05) and a significantly higher LDL-C level (P<0.05), and all the syndrome types groups had a significantly higher TG level (P<0.05); the Shaoyin syndrome group and Shaoyang syndrome group had a significantly higher HDL-C level than the Yangming syndrome group (P<0.05), and the Shaoyin syndrome group had a significantly higher TG level than the Shaoyang syndrome group (P<0.05). Conclusion For patients with type 2 diabetes, especially those who are old or have long duration of disease, it is necessary to pay attention to Yang-warming and cold-dispelling treatment. The levels of HDL-C and TG are different between the patients with different syndrome types, which has a certain reference value for six-meridian syndrome differentiation and treatment of diabetes. For patients with Shaoyin, Shaoyang, or Yangming syndrome, lipid regulation should be taken seriously in treatment.