Use of fluoxetine,diazepam, and behavior modification as therapy for treatment of anxiety-related disorders in dogs |
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| Authors: | Miguel Ibáñez Bernadette Anzola |
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| Institution: | 1. Universidad Complutense de Madrid, Facultad de Veterinaria, Clínica del Comportamiento Animal, Departamento de Producción Animal, Ciudad Universitaria, Madrid, Spain;2. Universidad Centrooccidental “Lisandro Alvarado,” Departamento de Producción Animal Núcleo Tarabana, Estado Lara, Venezuela;1. University of Northern Colorado, School of Nursing, Greeley, Colorado; Canine Education Center, LLC, Longmont, Colorado;2. Dog Days Training Center, Berthoud, Colorado;3. Northern Illinois University, College of Education, Technology, Research and Assessment DeKalb, Illinois;4. Colorado State University, Department of Animal Sciences, Fort Collins, Colorado;1. Department of Animal and Agriculture, Hartpury University, Hartpury, Gloucestershire, United Kingdom, GL19 3BE;2. Independent Researcher, Manchester, United Kingdom, M19 1LL;1. WALTHAM Centre for Pet Nutrition, Waltham-on-the-Wolds, Melton Mowbray, UK;2. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA;3. Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA;1. Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio;2. Department of Veterinary Preventive Medicine, The Ohio State University College of Veterinary Medicine, Columbus, Ohio;3. The Ohio State University College of Veterinary Medicine, Columbus, Ohio |
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| Abstract: | The objective of this study was to evaluate the use of fluoxetine, diazepam, and behavior modification for the treatment of a variety of anxiety disorders in dogs of different breeds, ages, and sexes that presented to a university veterinary behavior clinic. Forty dogs were enrolled in the study, and 34 completed it. The dogs were grouped into 2 major diagnostic categories, aggressive and anxious, according to the presenting signs. Moreover, the dogs further subdivided into 4 groups: neutered, intact, juveniles, and adults. Diazepam was administered orally, at a dosage of 0.3 mg/kg once a day for 4 weeks; fluoxetine was administered orally at a dosage of 1 mg/kg once a day for 10 weeks. The drugs were started simultaneously. The owners were given a behavior modification plan for their dogs that started from the first week of therapy. The behavior of the subjects was evaluated at 3 points in time. Clinical response was assessed by the supervising veterinarian and the owners. There were no significant differences (P > 0.05) between the groups studied in relation to the improvement achieved. There was a positive correlation (r > 0.44) between owner compliance with the treatment and the values obtained for the improvement achieved for each period. Clinical signs largely improved or were eliminated in 13 dogs (38%), 8 dogs (26%) showed moderate improvement, 5 dogs (12%) were slightly improved, and there were 8 dogs (24%) with no changes in clinical signs. |
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