Association between neurologic and cognitive dysfunction signs in a sample of aging dogs |
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| Authors: | L Golini R Colangeli V Tranquillo M Mariscoli |
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| Institution: | 1. Division of Clinical Radiology, Department of Clinical Veterinary Medicine, Vetsuisse-Faculty, University of Berne, 3012 Berne, Switzerland;2. Division of Neuroscience, Department of Clinical Veterinary Medicine, Vetsuisse-Faculty, University of Berne, 3012 Berne, Switzerland;3. Clinical Diagnostic Laboratory, Department of Clinical Veterinary Medicine, Vetsuisse-Faculty, University of Berne, 3012 Berne, Switzerland;1. Dovecote Veterinary Hospital, 5 Delven Lane, Castle Donington, Derby DE74 2LJ, UK;2. Davies Veterinary Specialists, Manor Farm Business Park, Higham Gobion, Hitchin SG5 3HR, UK |
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| Abstract: | In human neurology, patients with Alzheimer's disease show seizures and signs of motor deficits, such as movement disorders (i.e., restlessness, slowness, impaired gait, and, rarely, resting tremors). Because canine Cognitive Dysfunction Syndrome (CDS) is considered an Alzheimer-like disease in dogs, it might be possible to document concurrent behavioral and neurologic signs in aging canine patients as well. Twenty-one dogs (14 dogs with CDS-related signs, 7 normal dogs) greater than 7 years of age were studied. Owners completed a behavioral questionnaire and the dogs underwent a neurologic evaluation. Dogs with CDS were twice as likely to show neurologic deficits as dogs without CDS. However, based on this pilot study, a sample of 187 dogs affected with CDS are required to show statistically significant differences between the proportions of dogs with CDS and with neurologic signs and the proportions of control dogs without any of these disorders. |
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