Effects of cycloartane saponins from hairy roots of Astragalus membranaceus Bge., on human tumor cell targets |
| |
| Authors: | I Ionkova G Momekov P Proksch |
| |
| Institution: | 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, China;2. Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, P. R. China;1. Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei, Taiwan;2. School of Pharmacy, National Defense Medical Center, Taipei, Taiwan;3. Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan;4. National Heart & Lung Institute, Imperial College London, London, United Kingdom;5. Department of Anesthesiology, Cheng-Hsin General Hospital, Taipei, Taiwan;6. Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan;7. Department of Biotechnology, Asia University, Taichung, Taiwan |
| |
| Abstract: | For the first time three different natural compounds, isolated from hairy roots of Astragalus membranaceus, cultivated in airlift bioreactor were tested for their cytotoxic potential and apoptosis induction in a panel of human tumor cell lines. Root cultures, cultivated in bioreactor gave 18.5 g l? 1 dry wt roots with the highest astragaloside production in vitro up to now — 1.64% (astragaloside I), 1.12% (astragaloside II) and 1.08% (astragaloside III). In this manner the production in airlift bioreactor can be used as means of reliable supply of cycloartane saponins to extend the research to human clinical studies. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
