Chemical composition of the Lippia origanoides essential oils and their antigenotoxicity against bleomycin-induced DNA damage |
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| Authors: | Gloria Carolina Vicuña Elena E. Stashenko Jorge Luis Fuentes |
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| Affiliation: | 1. Microbiology and Environmental Mutagenesis Laboratory, Biology School, Faculty of Sciences, Industrial University of Santander, A.A. 678, Bucaramanga, Colombia;2. Research Center for Biomolecules (CIBIMOL), Research Center of Excellence (CENIVAM), Industrial University of Santander, A.A. 678, Bucaramanga, Colombia;1. Cátedra de Farmacología y Magister en Plantas Medicinales, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina;2. Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, C.A. de Buenos Aires, Argentina;3. Bioquímica y Fitoquímica, Facultad de Ciencias Agrarias y Forestales, Universidad Nacional de La Plata, La Plata, Argentina;1. Universidade Federal de Sergipe, Cidade Universitária Professor José Aloísio de Campos, Avenida Marechal Rondon s/n, Rosa Elze, São Cristóvão, Sergipe CEP 49100-000, Brazil;2. Embrapa Tabuleiros Costeiros, Av. Beira Mar, n° 3.250, Bairro Jardins, Aracaju, Sergipe CEP 49025-040, Brazil;3. Universidade Federal de Ceará, Campus do Pici, Avenida da Universidade 2853, Benfica, Fortaleza, Ceará CEP 60356-001, Brazil;1. Centre for Agricultural, Environmental and Biological Sciences, Federal University of Recôncavo da Bahia/UFRB, University Campus, Cruz das Almas/BA, 44380-000 Bahia, Brazil;2. Mountain Research Centre (CIMO)/School of Agriculture, Polytechnic Institute of Bragança, Campus de Sta Apolónia, Apt. 1172, 5301-854 Bragança, Portugal;3. Laboratório de Química de Produtos Naturais e Bioativos – Departamento de Ciências Exatas – Universidade Estadual de Feira de Santana, Campus Universitário, CEP: 44031-460, Feira de Santana, Bahia, Brazil;4. Horto Florestal – Departamento de Ciências Biológicas – Universidade Estadual de Feira de Santana, Campus Universitário, CEP: 44031-460, Feira de Santana, Bahia, Brazil;1. Centre for Agricultural, Environmental and Biological Sciences, Federal University of Recôncavo da Bahia/UFRB, University Campus, Cruz das Almas/BA 44380-000, Bahia, Brazil;2. Mountain Research Centre (CIMO)/School of Agriculture, Polytechnic Institute of Bragança, Campus de Sta Apolónia, Apt. 1172, 5301-854 Bragança, Portugal;3. Laboratório de Química de Produtos Naturais e Bioativos, Departamento de Ciências Exatas, Universidade Estadual de Feira de Santana, Campus Universitário, CEP: 44031-460 Feira de Santana, Bahia, Brazil;4. Horto Florestal, Departamento de Ciências Biológicas, Universidade Estadual de Feira de Santana, Campus Universitário, CEP: 44031-460 Feira de Santana, Bahia, Brazil |
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| Abstract: | The present work evaluated the chemical composition of the essential oils (EO) obtained from Lippia origanoides and their DNA protective effect against bleomycin-induced genotoxicity. L. origanoides EO chemical composition was determined by gas chromatography–mass spectrometry (GC–MS). The major compounds of the L. origanoides EOs were thymol (34–58%) and carvacrol (26%). The antigenotoxic effects of the EOs, major compounds and standard compound (epigallocatechin gallate) were assayed in co-incubation procedures using the SOS chromotest in Escherichia coli. Both EOs and their major compounds protected bacterial cells against bleomycin-induced genotoxicity indicating that these two compounds were principally responsible for the antigenotoxicity detected in the oils. Thymol and carvacrol antigenotoxicity was lower than those observed with epigallocatechin gallate. The results were discussed in relation to the chemopreventive potential of L. origanoides EOs and their major components, carvacrol and thymol. |
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