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Experimental Albizia versicolor poisoning in sheep and its successful treatment with pyridoxine hydrochloride.
Authors:B Gummow  S S Bastianello  L Labuschagne  G L Erasmus
Institution:Department of Infectious Diseases, Faculty of Veterinary Science, Onderstepoort.
Abstract:Five sheep developed severe nervous signs after being drenched with Albizia versicolor pod-material. Four of these sheep were treated with pyridoxine hydrochloride (a vitamin B6) when the symptoms of toxicity became life-threatening. All the treated sheep recovered dramatically and completely after treatment while the untreated one died 2 h after receiving pod-material. A therapeutic dose of 20-25 mg pyridoxine hydrochloride/kg body mass given twice with an 8 h interval is the recommended treatment regimen. The route of administration will depend on the severity of symptoms. Chemical pathology and post-mortem findings are discussed.
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