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Decreased erythrocyte potassium concentration associated with exercise-related myopathy in horses
Authors:F T Bain  A M Merritt
Institution:Peterson & Smith Equine Hospital, Ocala, FL 32674.
Abstract:To investigate the possibility that a disorder of potassium balance may have a role in the development of equine rhabdomyolysis, the potassium concentration within erythrocytes (RBC K+]) and plasma (P K+]) was measured in 3 groups of horses: group 1, eight 2-year-old fillies that had postexercise muscle soreness within 48 hours of sample collection; group 2, ten 2-year-old fillies subjected to identical management and training conditions (as fillies of group 1) and that did not have signs of myopathy; and group 3, 32 yearlings of both sexes on the farm of origin of groups 1 and 2 that were pastured and not in training. Creatine kinase activity in serum from horses of groups 1 and 2 was also measured. The mean P K+] was not significantly different between groups, whereas the mean RBC K+] was significantly (P less than 0.01) lower in group-1 fillies vs group-2 fillies and group-3 horses. Group-1 fillies also had markedly high serum creatine kinase activity. Results of the study revealed significantly lower RBC K+] in horses that had had signs of myopathy within the preceding 48 hours. This does not prove a causal relationship between RBC potassium depletion and myopathy, but does suggest that decreased RBC K+] may be observed in horses with exercise-related myopathy.
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