| 硒对小鼠血清中细胞因子水平的调控作用研究 |
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| 引用本文： | 荔霞,刘永明,齐志明,孟嘉仁,刘世祥,李建喜.硒对小鼠血清中细胞因子水平的调控作用研究[J].中国畜牧兽医,2007,34(6):98-100. |
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| 作者姓名： | 荔霞 刘永明 齐志明 孟嘉仁 刘世祥 李建喜 |
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| 作者单位： | 中国农业科学院兰州畜牧与兽药研究所，兰州 730050 |
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| 基金项目： | 中国农业科学院兰州畜牧与兽药研究所基金 |
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| 摘 要： | 通过给小鼠灌胃Na2SeO3，观察了0.025、0.05和0.1 mg/kg剂量的硒被应用后对小鼠血清中细胞因子IL-2、IL-6和TNF-α水平的影响，结果表明，硒能明显降低正常小鼠血清中的IL-2及TNF-α水平，且呈剂量依赖关系; 对IL-6水平则有显著的升高作用，即呈正相关。该结果提示，微量元素硒对细胞因子水平有显著的调控作用。
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| 关 键 词： | 硒 细胞因子 白细胞介素 肿瘤坏死因子 小鼠 |
| 文章编号： | 1671-7236（2007）06-0098-02 |
| 修稿时间： | 2006-11-16 |
Effect of Se on Levels of IL-2,IL- 6 and TNF-α in Murine Serum |
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| LI Xia,LIU Yong-ming,QI Zhi-ming,MENG Jia-ren,LIU Shi-xiang,LI Jian-xi.Effect of Se on Levels of IL-2,IL- 6 and TNF-α in Murine Serum[J].China Animal Husbandry & Veterinary Medicine,2007,34(6):98-100. |
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| Authors: | LI Xia LIU Yong-ming QI Zhi-ming MENG Jia-ren LIU Shi-xiang LI Jian-xi |
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| Institution: | Lanzhou Institute of Animal Sciences and Veterinary Pharmaceutics of CAAS， Lanzhou 730050,China |
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| Abstract: | Changes of levels of IL-2， IL-6 and TNF-α in sera of mice were observed after the mice were treated with different doses Se of 0.025 mg/kg， 0.05 mg/kg and 0.1 mg/kg respectively. Results were as follows. Se had functions to decrease the level of IL-2 in a dose dependent manner and lower the level of TNF-α significantly， and on the contrary the level of IL-6 significantly. The results showed that Se can enhance immune functions and adjust the levels of Cytokines in mice. |
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| Keywords: | Se cytokines IL-2 IL-6 TNF-α mice |
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