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Narcotic tolerance and dependence: lack of relationship with serotonin turnover in the brain |
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| Authors: | D L Cheney A Goldstein S Algeri E Costa |
| Abstract: | Serotonin turnover was measured in mouse brain by means of the conversion of radioactivity from labeled tryptophan into serotonin. Animals with a high degree of tolerance to and physical dependence on morphine did not differ from control mice. |
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