Inhibitory effects of <Emphasis Type="SmallCaps">l</Emphasis>-pipecolic acid from the edible mushroom, <Emphasis Type="Italic">Sarcodon aspratus</Emphasis>, on angiotensin I-converting enzyme |
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| Authors: | Masaaki Kiyoto Shingo Saito Kazuyuki Hattori Nam-Seok Cho Takaaki Hara Yuzo Yagi Masakazu Aoyama |
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| Institution: | (1) Department of Applied and Environmental Chemistry, Kitami Institute of Technology, 165 Koen-cho, Kitami 090-8507, Japan;(2) Graduate School of Science and Engineering, Saitama University, Saitama 338-8570, Japan;(3) College of Agriculture, Life and Environmental Science, Chungbuk National University, Cheongju, 361-763, Korea;(4) Hakuju Life Science Co., Ltd., Tokyo 173-0004, Japan |
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| Abstract: | The aqueous extract of the edible mushroom Sarcodon aspratus showed inhibitory effects against angiotensin I-converting enzyme (ACE). l-Pipecolic acid (l-piperidine-2-carboxylic acid) was isolated from a hot-water extract in a 0.02% yield as an active principle. The mode of
inhibition of l-pipecolic acid was found to be competitive, whereas its d-isomer showed no significant inhibitory effects against ACE, suggesting that the configuration of the carboxyl group in the
molecule plays an important role in the enzyme inhibition. |
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| Keywords: | Angiotensin I-converting enzyme (ACE) Antihypertensive agent l-Pipecolic acid" target="_blank">l-Pipecolic acid Sarcodon aspratus |
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