Yohimbine increases plasma insulin concentrations and reverses xylazine-induced hypoinsulinemia in dogs |
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Authors: | W H Hsu |
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Affiliation: | Department of Veterinary Physiology and Pharmacology, Iowa State University, Ames 50011. |
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Abstract: | Xylazine (1.1 mg/kg of body weight, IV), an alpha 2-adrenoreceptor agonist, suppressed the increase in plasma insulin concentration induced by glucose (0.6 g/kg, IV) in dogs. Yohimbine (0.11 mg/kg, IV), an alpha 2-adrenoreceptor antagonist, given 5 minutes after xylazine, reversed effects of xylazine, whereas yohimbine alone increased plasma insulin and decreased plasma glucose concentrations. Seemingly, alpha 2-adrenoreceptors exert a negative control of insulin release. |
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