| 多发性骨髓瘤骨病的机制与治疗 |
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| 引用本文： | 庄文越,;张吉林. 多发性骨髓瘤骨病的机制与治疗[J]. 吉林林学院学报, 2009, 0(6): 507-512 |
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| 作者姓名： | 庄文越, 张吉林 |
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| 作者单位： | [1]北华大学医学检验学院,吉林吉林132013; [2]苏州大学附属第一医院,江苏苏州215000 |
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| 摘 要： | 多发性骨髓瘤是恶性克隆性浆细胞疾病,骨髓瘤骨病是其重要的临床表现之一.多年来,对骨髓瘤骨病的溶骨性病变机制的研究主要集中在破骨细胞数量和活性的增加.近些年来的研究发现,成骨细胞数量和活性的减低也参与了溶骨性病变的发生和发展,对骨髓瘤骨病病理生理机制的研究促进了新的靶向性药物研发.
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| 关 键 词： | 多发性骨髓瘤骨病 机制 治疗 |
Mechanism and Treatment on Multiple Myeloma Bone Disease |
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| Affiliation: | ZHUANG Wen-yue ,ZHANG Ji-lin ( 1. Medical Inspection College of Beihua University, Jilin 132013, China ; 2. The First Affiliated Hospital of Soochow University, Suzhou 215000, China) |
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| Abstract: | Multiple myeloma is a plasma cell malignancy and bone disease is one of the important clinical features.For decades,the study on the mechanism of myeloma osteolytic disease mainly focused on the enhanced osteoclasts recruitment and activity.Recently,decreased osteoblasts number and activity were also found to be involved in the pathogenesis of myeloma bone disease.The progress in acknowledge of the pathophysiology of myeloma bone disease leaded to identify new therapeutic targets. |
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| Keywords: | Multiple myeloma bone disease Mechanism Treatment |
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