| 氨基甲酸苯丙酮肟酯类化合物的合成及生物活性 |
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| 引用本文： | 林美娟,袁莉萍,曹瑾,倪长春,沈宙,郭庆铭,张一宾. 氨基甲酸苯丙酮肟酯类化合物的合成及生物活性[J]. 农药学学报, 2006, 8(2): 104-108 |
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| 作者姓名： | 林美娟 袁莉萍 曹瑾 倪长春 沈宙 郭庆铭 张一宾 |
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| 作者单位： | 华东理工大学药学院,上海,200237;上海市农药研究所,上海,200032 |
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| 基金项目： | 国家“十五”科技攻关计划(2004BA308A22-3)，上海市科技攻关计划(034319251)，国家重点基础研究发展计划(“973”计划)资助项目2003CB114401) |
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| 摘 要： | 为寻找高活性的新农药化合物,以3-取代氨基-1-芳基丙酮-1-肟与氨基甲酸酯反应,设计并合成了19个氨基甲酸苯丙酮肟酯衍生物,其结构均经核磁共振氢谱和元素分析确证。初步的生物活性测定结果表明,化合物具有一定的生物活性,其中 c11 在浓度为500 mg/L时,对蚜虫Aphis craccivora的致死率达到90%以上; c16和c17 在1 000 mg/L时,对朱砂叶螨Tetranychus cinabarinus 的致死率达到100%。
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| 关 键 词： | 取代苯丙酮肟 氨基甲酸肟酯 合成 生物活性 |
| 文章编号： | 1008-7303(2006)02-0104-05 |
| 收稿时间： | 2005-12-15 |
| 修稿时间： | 2006-03-27 |
Synthesis and Bioactivity of Phenylpropan-1-one Oxime Carbamate Derivatives |
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| LIN Mei-juan,YUAN Li-ping,CAO Jin,NI Chang-chun,SHEN Zhou,GUO Qing-ming and ZHANG Yi-bin. Synthesis and Bioactivity of Phenylpropan-1-one Oxime Carbamate Derivatives[J]. Chinese Journal of Pesticide Science, 2006, 8(2): 104-108 |
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| Authors: | LIN Mei-juan YUAN Li-ping CAO Jin NI Chang-chun SHEN Zhou GUO Qing-ming ZHANG Yi-bin |
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| Affiliation: | 1.East China University of Science and Technology,Pharmaceutical Institute,Shanghai 200237,China2.Shanghai Pesticide Research Institute,Shanghai 200032,China |
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| Abstract: | In search of novel pesticide compound with high bioactivity,nineteen phenylpropan-1-oneoxime carbamate derivatives were designed and synthesized by the reaction of 3-substitutedamino-1-arypropan-1-one oxime with carbamate.The structures of all novel compounds were confirmed by~1H NMR and elemental analysis.Preliminary bioassays showed that somecompounds exhibitedcertain bioactivities.The mortality of c_11to Aphis craccivora was over 90% at the concentration of500 mg/L;The mortality of c_16 and c_17 to Tetranychus cinabarinus was 100% at 1 000 mg/L. |
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| Keywords: | substituted phenyl-propan-1-one oxime oxime carbamate synthesis bioactivity |
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