Passiflora alata and Passiflora edulis spray-dried aqueous extracts inhibit inflammation in mouse model of pleurisy |
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Authors: | Vargas A J Geremias D S Provensi G Fornari P E Reginatto F H Gosmann G Schenkel E P Fröde T S |
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Affiliation: | Departamento de Análises Clínicas, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Campus Universitário-Trindade, 88040-970, Florianópolis, SC, Brazil. |
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Abstract: | The aqueous leaves extracts of Passiflora alata (100-300 mg/kg, i.p.) and Passiflora edulis (100-1000 mg/kg, i.p.) possess a significant antiinflammatory activity on carrageenan-induced pleurisy in mice. Treatment with the extracts inhibited leukocyte migration and reduced the formation of exudate. Moreover, a significant inhibition of myeloperoxidase and adenosine-deaminase activities was observed at the doses tested (100 or 250 mg/kg, i.p.). At the same doses, a significant decrease of serum C-reactive protein was observed. |
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Keywords: | Passiflora alata Passiflora edulis Antiinflammatory activity Pleurisy |
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