| Synthesis and Characterization of 1, 3, 4 - Oxadiazolines Derivatives |
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| 作者姓名： | HU Jun-fu~ |
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| 作者单位： | 1. Department of Chemistry, Yunyang Normal College, Danjiangkou 442700, China; 2. Institute of Chemical Engineering, South China University of Technology, Guangzhou 510640, China |
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| 摘 要： | 1,3,4-oxadiazolines are found to possess significant biological activities such as antibacterial,antifungal effects.According to these,we designed and synthesized some new 1,3,4-oxadiazoline derivatives.First,Ethyl 4-methylbenzoate was prepared by reaction of 4-methyl benzoic acid with anhydrous ethanol in the presence of sulfuric acid.This propound reacted with hydrazine hydrate in the presence of anhydrous ethanol as solvent to give 4-methylhydrazin(1).In the presence of anhydrous ethanol,(1) reacted with aromatic aldehydes to produce corresponding hydrazones(2a~2j).Then 2a~2j cyclodehydrated with acetic anhydride to afford the title compounds(3a~3j).The mild reactions and good yields are the merits of this method.The title structures of 3a~3j were confirmed by elementary analyses,IR,~(1)H NMR,and MS spectroscopy.
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| 关 键 词： | 1 3 4 - oxadiazoles synthesis characterization |
| 收稿时间： | 2005/12/16 0:00:00 |
| 修稿时间： | 2005/12/16 0:00:00 |
Synthesis and Characterization of 1, 3, 4 - Oxadiazolines Derivatives |
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| HU Jun-fu.Synthesis and Characterization of 1, 3, 4 - Oxadiazolines Derivatives[J].Storage & Process,2006(4):129-132. |
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| Authors: | HU Jun-fu |
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| Institution: | 1. Department of Chemistry, Yunyang Normal College, Danjiangkou 442700, China; 2. Institute of Chemical Engineering, South China University of Technology, Guangzhou 510640, China |
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| Abstract: | 1,3,4-oxadiazolines are found to possess significant biological activities such as antibacterial,antifungal effects.According to these,we designed and synthesized some new 1,3,4-oxadiazoline derivatives.First,Ethyl 4-methylbenzoate was prepared by reaction of 4-methyl benzoic acid with anhydrous ethanol in the presence of sulfuric acid.This propound reacted with hydrazine hydrate in the presence of anhydrous ethanol as solvent to give 4-methylhydrazin(1).In the presence of anhydrous ethanol,(1) reacted with aromatic aldehydes to produce corresponding hydrazones(2a~2j).Then 2a~2j cyclodehydrated with acetic anhydride to afford the title compounds(3a~3j).The mild reactions and good yields are the merits of this method.The title structures of 3a~3j were confirmed by elementary analyses,IR,~(1)H NMR,and MS spectroscopy. |
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| Keywords: | 1 3 4 - oxadiazoles synthesis characterization |
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