| Toll样受体研究进展 |
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| 引用本文： | 赵文华,夏雪山.Toll样受体研究进展[J].动物医学进展,2007,28(10):89-92. |
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| 作者姓名： | 赵文华 夏雪山 |
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| 作者单位： | 1. 中国医学科学院/中国协和医科大学医学生物研究所,云南昆明,650118;云南省热带亚热带动物病毒病重点实验室,云南昆明,650224
2. 昆明理工大学,云南昆明,650224 |
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| 摘 要： | Toll-like receptors(TLRs)是存在于机体的一类重要的模式识别受体,在机体天然免疫中起着重要的作用.TLRs还是连接天然免疫和适应性免疫的桥梁.目前TLR1-9研究的较清楚和详尽.不同TLRs识别的病原体相关分子模式各不相同.TLRs介导的机体信号传导途径分为MyD88依赖性和非MyD88依赖性.多种生物TLRs已被克隆和表达,通过进化分析,脊椎动物的TLRs可被分为6大基因家族,识别相似PAMP的TLRs聚为一簇.TLRs编码序列和功能是高度保守的.
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| 关 键 词： | TLRs 天然免疫 病原相关分子模式 信号传导途径 |
| 文章编号： | 1007-5038（2007）06-0089-04 |
| 修稿时间： | 2006-12-18 |
Advance in the Field of Toll-like Receptors(TLRs) |
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| ZHAO Wen-hua,XIA Xue-shan.Advance in the Field of Toll-like Receptors(TLRs)[J].Progress In Veterinary Medicine,2007,28(10):89-92. |
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| Authors: | ZHAO Wen-hua XIA Xue-shan |
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| Institution: | 1. Institute of Medical Biology, Chinese Academy of Medical Science/Peking Union Medical College, Kunming,Yunnan, 650118, China; 2. Yunnan Tropical and Subtropical Animal Viral Diseases Laboratory, Kunming , Yunnan , 650224,China 3. Kunming University of Science and Technology, Kunming , Yunnan ,650224,China |
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| Abstract: | Toll-like receptors(TLRs) are probably the most important class of pattern-recognition receptors(PRRs)and play an important role in the host innate immune response.TLRs bridge the innate immune and adaptive immune.So far,TLR1-9 have been studied detailed.Different TLRs recognize different pathogen-associated molecular patterns(PAMPs).The signaling pathways mediated by the TLRs can be divided into two types: the MyD88-dependent and the MyD88-independent.TLRs of many kind species have been cloned and expressed.Through the evolution analysis,there are 6 major families of vertebrate TLRs.TLRs recognizing the same kind PAMPs are in the same family.The coding sequences and function of TLRs are highly conserved. |
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| Keywords: | Toll-like receptors innate immunity adaptive immunity |
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