Effect of Fufang Zhenzhu Tiaozhi capsule on serum lipids and inflammatory factors in rabbit abdominal aortic restenosis model

AIM: To investigate the effect of Fufang Zhenzhu Tiaozhi capsule (FTZ) on serum lipids and inflammatory factors in rabbits with abdorminal aortic restenosis after balloon angioplasty.METHODS: New Zealand white rabbits (n=30) were divided into 5 groups. Except blank control group, the rabbits in other groups were used to establish abdominal aortic endothelium exfoliative vascular stenosis model. After 4 weeks of high-fat diet feeding, the animals in restenosis model group and drug treatment groups underwent percutaneous balloon dilatation in the stenosis. The angiographic stenosis was analyzed by a two-dimensional quantitative coronary angiography workstation with a digital subtraction X-ray machine. Blood samples were taken during angiography and the profiles of serum lipids and cytokines were measured. The expression of nuclear factor-κB (NF-κB) in the blood vessels was determined by immunohistochemistry.RESULTS: Angiography confirmed that the rates of area stenosis and diameter stenosis were significantly decreased in treatment groups compared with restenosis model group (P<0.01). Compared with restenosis model group, the serum lipid profiles and cytokine concentrations in drug treatment groups were significantly decreased (P<0.05). Immunohistochemistry showed the expression of NF-κB in restenosis model group was significantly higher than that in blank control group and drug treatment groups (P<0.05).CONCLUSION: FTZ significantly reduces the blood lipids and inflammatory factors in abdominal aortic restenosis model, and the anti-inflammatory effect may be related to the regulation of NF-κB pathway to inhibit the production of various inflammatory factors.