Research progress of glioma cell origin

Glioma, a common primary brain tumor, is considered to be incurable, and easy to relapse. The median survival of the patients with glioma after treatment is only 15 to 19 months. The high heterogeneity of glioma is the main reason leading to poor clinical treatment, and the underlying mechanism is closely related to the cell origin of glioma. Therefore, to elucidate the cell origin of glioma is important to further study the mechanism of tumor formation and develop effective treatment programs. For a long time, studies have attempted to speculate on the cell origin of glioma based on the morphological characteristics, but agreements still haven't been reached. This review focuses on the most probable origin cells, such as neural stem cells, astrocytes, oligodendrocyte progenitor cells and neurons.