Association of S100B polymorphisms with systemic lupus erythematosus in Guangxi population |
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Authors: | LU Yu-lan LIU Chun-hong WANG Rong HUANG Hua-tuo ZENG Yong-long WEI Ye-sheng LAN Yan |
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Institution: | 1. Department of Clinical Laboratory, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China;
2. Department of Dermatology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China |
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Abstract: | AIM: To explore the association of rs9984765, rs2839356 and rs2186358 polymorphisms in S100B gene with the susceptibility to systemic lupus erythematosus (SLE). METHODS: SLE patients (n=313) and age-and sex-matched healthy controls (n=396) were recruited in this study. The genotypes of the 3 sites were determined by single-base extension PCR (SBE-PCR) and DNA sequencing. RESULTS: No difference between the SLE patients and controls in the genotype and allele frequencies of rs9984765 and rs2186358 was observed. However, the frequency distribution of rs2839356 C allele was significantly different in the 2 groups (P=0.040). Stratification analysis showed that the frequency of rs2839356 C allele was higher in the patients with neurologic disorder than the patients without neurologic disorder (P=0.023).CONCLUSION: S100B gene rs9984765 and rs2186358 polymorphisms may not contribute to the susceptibility of SLE in Guangxi population. The rs2839356 C allele might be correlated with the SLE patients with neurologic disorder. |
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Keywords: | S100B gene Genetic polymorphism Systemic lupus erythematosus |
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