Progress on role of CCN1 in pulmonary diseases |
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Authors: | DONG Nian SONG Chen-jian QIU Dan-ping CHEN Cheng-shui |
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Institution: | Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, China |
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Abstract: | Cysteine-rich angiogenic inducer 61 (Cyr61/CCN1) is an extracellular matrix-associated signaling protein consisting of 381 amino-acid residues, which has the regulatory function for a multitude of cellular responses. The pleiotropic effects of CCN1 on the initiation and resolution of inflammation as well as oncogenesis and development of tumor were reported. According to the numerous data from experimental and clinical studies, this article provides an overview on CCN1 and summarizes the latest understanding of the role of CCN1 in pulmonary diseases. |
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Keywords: | CCN1 Acute lung injury Chronic obstructive pulmonary disease Lung cancer |
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