山羊促卵泡素受体基因研究进展

促卵泡素受体（FSHR）作为影响动物繁殖力的主效基因,已在不同物种中被广泛和持续地研究。作者归纳和分析了山羊FSHR基因的结构及其蛋白质的结构、作用机制、表达范围和规律,总结了该基因单核苷酸多态性的遗传效应,发现山羊FSHR基因的生物信息和基因效应相关研究比较深入,且近期在信号传导方面的研究证实FSHR基因是卵泡形成和发育过程中的关键因素;与不同种群繁殖性能的关联分析提示,FSHR基因的某些单核苷酸突变位点可作为遗传标记辅助选择的依据,但不同山羊种群中的突变效应仍需进一步证实。

Research Progress on the Follicle Stimulating Hormone Receptor Gene in Goats

Follicle-stimulating hormone receptor (FSHR) gene,as a major gene affecting animal fertility,had been extensively and continuously studied in different species.The authors summarized and analyzed the structure of the goat FSHR gene and the corresponding protein's structure,action mechanism,expression scope and regularity,as well as the genetic effect of single nucleotide polymorphisms of the gene,and found that the research on the biological information and gene effects of goat FSHR gene had been carried out in depth,and the recent studies in signal transduction confirmed that FSHR gene was the key factor in the process of formation and development of ovarian follicles.Correlation analysis with reproductive performance of different populations suggested that some single nucleotide mutation sites of FSHR gene could be used as marker-assisted selection,but the mutation effects in different goat populations need to be further verified.