The virulence of strains of Corynebacterium bovis in the mammary gland of the mouse and the effect of corynebacterial mastitis on subsequent infection with Staphylococcus aureus期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

The virulence of strains of Corynebacterium bovis in the mammary gland of the mouse and the effect of corynebacterial mastitis on subsequent infection with Staphylococcus aureus

Authors:	T Honkanen-Buzalski J C Anderson A J Bramley

Affiliation:	1. National Institute for Research in Dairying, Shinfield, Reading, U.K.;2. Agricultural and Food Research Council Institute for Research on Animal Diseases, Compton, Newbury, U.K.;1. Asia-Pacific Centre for Animal Health, Faculty of Veterinary Science, The University of Melbourne, 250 Princes Hwy, Werribee, VIC 3030, Australia;2. Asia-Pacific Centre for Animal Health, Faculty of Veterinary Science, The University of Melbourne, Cnr Flemington Road and Park Drive, Parkville, VIC 3052, Australia;1. Cardiff University, School of Medicine, Department of Child Health, 5th floor University Hospital of Wales, Cardiff CF14 4XN, UK;2. Sebha University, Faculty of Engineering and Technology, Medical Laboratory Sciences Department, PO Box 68, Libya;3. INRA, UMR 1225, IHAP, 31076 Toulouse, France;4. Université de Toulouse, INP, ENVT, UMR1225, IHAP, 31076 Toulouse, France;5. Cardiff University, School of Medicine, Institute of Infection and Immunity, Cardiff CF14 4XN, UK;6. J. Craig Venter Institute, Rockville, MD, USA;1. Department of Radiology, Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom;2. Department of Nuclear Medicine, Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom;3. Northern Oesophagogastric Cancer Unit, Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom;4. Department of Anaesthesia, Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom;5. Newcastle University, Newcastle Upon Tyne, United Kingdom

Abstract:	Strains of Corynebacterium bovis which were isolated from clinically-infected and normal bovine udders showed a spectrum of virulence in the mammary gland of the mouse which was consistent with their origin. C. bovis strain P3 had a predilection for teat keratin and behaved as an environmental organism which casually invaded the mammary gland. A neutrophil infiltration in the mammary gland induced by endotoxin before challenge with strain P3 resulted in a reduction in bacterial numbers, but a neutrophil infiltration after corynebacterial challenge did not result in any reduction. Glands in which a neutrophil response was elicited by infection with a virulent or avirulent strain of C. bovis were subsequently challenged with an avirulent or virulent strain of Staph. aureus respectively. In neither case was the establishment of Staph. aureus prevented by the prior C. bovis infection; nor was there any significant influence on bacterial numbers. The results are discussed in relation to the role of C. bovis in udder infections of dairy cattle.

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