| 鸡传染性鼻炎二价油乳剂灭活疫苗的近期免疫效力检验 |
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| 引用本文： | 苗得园,张培君,龚玉梅,冯文达,冯杉.鸡传染性鼻炎二价油乳剂灭活疫苗的近期免疫效力检验[J].华北农学报,2000,15(2):138-142. |
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| 作者姓名： | 苗得园 张培君 龚玉梅 冯文达 冯杉 |
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| 作者单位： | 1. 北京市农林科学院畜牧兽医研究所,北京,100089
2. 中国兽药监察所,北京,100081 |
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| 基金项目： | 农业部畜牧业重点科研项目，95牧-02-04-18， |
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| 摘 要： | 应用３批鸡传染性鼻炎价油乳剂灭活疫苗进行了安全性和近期免疫效力检验，安全性试验采用１５只鸡进行，胸肌注射疫苗４￣５ｍＬ／只后，逐日观察，结果鸡只食欲、精神未见异常，２周后观察，注射部位未发现明显异常和病变。用该疫苗免疫（０．５ｍＬ／ｋｗ ）后的鸡只对Ａ型高致病力菌株的攻击保护率可达１００％，对Ｃ型高致病力菌株的攻击保护率为９３．３％。采用Ｂ－ＥＬＩＳＡ和ＳＰＺＡ对鸡群的抗体水平的评估表明该疫苗可激发产生较高的抗体水平。
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| 关 键 词： | 鸡传染性鼻炎 二价油乳剂灭活疫苗 免疫效力 |
| 修稿时间： | 1999-07-14 |
Tests of Efficacy of Bivalent Inactivated Oil Adjuvant Vaccine to Avian Infectious Coryza |
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| MIAO De-yuan,ZHANG Pei-jun,GONG Yu-mei,FENG Wen-da,FENG Shan.Tests of Efficacy of Bivalent Inactivated Oil Adjuvant Vaccine to Avian Infectious Coryza[J].Acta Agriculturae Boreali-Sinica,2000,15(2):138-142. |
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| Authors: | MIAO De-yuan ZHANG Pei-jun GONG Yu-mei FENG Wen-da FENG Shan |
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| Abstract: | Three batches of bivalent inactivated oil adjuvant vaccine to avian infectious coryza were produced and the safety and efficacy of them were also evaluated in this study.15 chickens were injected intramuscularly with 4-5 mL vaccine,there was no significant sign to be observed,and no lesions on the injecting spot after 2 weeks.The vaccine could achieve a protective rate about 100% against challenge of high virulent strain of serovar A(Hp8)and 93 3% against challenge of serovar C(H18).The antibodies were also tested in this study by and SPA,and the results showed that the vaccine could stimulate high levels of antibody to Hpg.All the results demonstrated the good safty and efficacy of the vaccine,and it could play a big role in the prevention of infectious coryza in China. |
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| Keywords: | Bivalent inactivated oil adjuvant vaccine Infectious coryza Safety Efficacy |
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