B-cell leukemia in a sheep |
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Authors: | Valentine B A McDonough S P |
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Institution: | Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis 97331, USA. beth.valentine@orst.edu |
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Abstract: | Necropsy examination was performed on an 8.5-year-old Finnish ewe euthanatized because of progressive respiratory distress, cachexia, and weakness. Significant postmortem findings included a diffusely enlarged, dark-red friable liver, mild splenomegaly, and mild mesenteric lymphadenopathy. Examination of multiple tissue sections revealed intravascular atypical mononuclear cells in all tissues examined, with a leukemic pattern of infiltration of mesenteric lymph nodes, liver, lung, and spleen. Neoplastic cells were positive for CD79a and negative for CD-3, BLA.36, and CD68 leukocytic markers. The final diagnosis was B-cell leukemia. |
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