A novel hepatoprotective saponin from Celosia cristata L. |
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| Authors: | Yan Wang Ziyang Lou Qing-Bin Wu Mei-Li Guo |
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| Institution: | a Department of Pharmacognosy, College of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P.R. China;b Department of Pharmaceutical Analysis Center, College of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P.R. China |
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| Abstract: | A new saponin, cristatain (1), together with four other saponins, celosin A (2), celosin B (3), celosin C (4) and celosin D (5) were isolated from the seeds of Celosia cristata L. (Amaranthaceae). Their structures were established by chemical and spectroscopic analyses. For the first time, the saponins were found in C. cristata L. In addition, compound 1 exhibited significant hepatoprotective effect on carbon tetrachloride (CCl4)- and N,N-dimethylformamide (DMF)–induced hepatotoxicity in mice, which were evidenced by significant decreases in the values of asparate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) of serum and histopathological examinations compared to controls. |
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| Keywords: | Amaranthaceae Celosia cristata L Cristatain Hepatoprotective effect |
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