DNAs of the two mating-type alleles of Neurospora crassa are highly dissimilar |
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Authors: | N L Glass S J Vollmer C Staben J Grotelueschen R L Metzenberg C Yanofsky |
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Affiliation: | Department of Physiological Chemistry, University of Wisconsin, Madison 53706. |
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Abstract: | The mating-type alleles A and a of Neurospora crassa control mating in the sexual cycle and function in establishing heterokaryon incompatibility in the vegetative cycle. The A and a alleles were cloned, and they were shown to encode both the sexual functions and vegetative incompatibility. The mating-type clones contain nonhomologous DNA segments that are flanked by common DNA sequences. Neurospora crassa and all heterothallic and pseudohomothallic Neurospora species contain a single copy of one mating-type sequence or the other within each haploid genome. The six known self-fertile homothallic isolates contain an A homolog, but only one species also contains a homologous sequences. Homothallism in these species is not due to mating-type switching, as it is in Saccharomyces cerevisiae. |
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