Postanesthetic equine myopathy suggestive of malignant hyperthermia. A case report |
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Authors: | L Klein N Ailes G E Fackelman E Kellon H Rosenberg |
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Affiliation: | Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine, New Bolton Center 19348. |
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Abstract: | Signs of malignant hyperthermia, including progressive increases in PaCO2, skin temperature and heart rate, and elevated serum levels of potassium, inorganic phosphate, and creatine kinase, were identified in a halothane-anesthetized horse. Treatment was discontinuing halothane administration, applying ice and cold fluids, and hyperventilating with 100% oxygen. After an initial recovery, bilateral hindlimb myopathy and pigmenturia developed. The myopathy resolved after treatment with oral dantrolene, IV fluids, and hydrocortisone. Results of caffeine-halothane challenge, using semimembranosus muscle collected 2 weeks after the episode, were considered within normal limits for horses. The intraoperative abnormalities were evidently predictive of postanesthetic myopathy but the cause in this horse remained unclear. |
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